2 Of interest, only eight of the 29 children fulfilled the WHO

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pandora rings Severe hypotension is very uncommon in children, as shown by the very small number of children (n=29) with this condition who were enrolled in the FEAST trial; all of these children were randomised to receive either colloid of saline boluses.2 Of interest, only eight of the 29 children fulfilled the WHO definition of shock and all eight died.Overall, severe dehydration without diarrhoea was present in 236 children (7.5%) in FEAST, and we found no evidence that boluses were of benefit; there were 38/173 (22%) deaths in the bolus arm versus 8/58 (13.8%) in the control (relative risk 1.59, 95% confidence interval 0.79 to 3.21).11Change led by FEASTThe FEAST trial was praised for demonstrating how rigorous clinical research can be done in resource poor settings. Subsequently, the findings have been widely debated, as they challenged the primacy of bolus resuscitation as a lifesaving intervention for paediatric shock in resource limited settings and raised questions about their use elsewhere. Following publication of a systematic review of the evidence,3 Mdicins Sans Frontires revised its paediatric shock guideline in March 2012.A meeting hosted by the Kenyan Paediatric Association in October 2012 raised concern about WHO’s lack of response to the FEAST results pandora rings.

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