The largest trial ever published in this area

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pandora essence None of the interventions examined showed clear efficacy for length of stay among inpatients.Conclusions Evidence shows the effectiveness and superiority of adrenaline for outcomes of most clinical relevance among outpatients with acute bronchiolitis, and evidence from a single precise trial for combined adrenaline and dexamethasone. The largest trial ever published in this area, concerning 800 children in Canada, used a factorial design to examine adrenaline and dexamethasone, alone or combined pandora rings, compared with placebo.16 Another trial completed concurrently in the United States compared dexamethasone with placebo in a sample of 600 children.17 These two large trials add substantially to the evidence and provide a strong signal for further synthesis work.18These recent trials also raise new questions and potentially novel approaches to the acute management of bronchiolitis that warrant closer investigation. Specifically, one trial showed a 35% relative reduction on rates of admission to hospital with combined adrenaline and dexamethasone treatment compared with placebo.16 Previously, a smaller trial was the first to show the effectiveness of oral dexamethasone in reducing hospital admissions in outpatients with acute bronchiolitis.19 The unique feature of this trial, among others that did not show effectiveness, was that high dose steroids were administered along with a bronchodilator (salbutamol) according to a defined protocol rather than at the discretion of the attending physician. pandora essence

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